Table 2.
Hazard ratios and 95% confidence intervals for the risk of overall cancer for quartiles and standardized values of serum Pi levels
| |
Overall cancer |
Overall cancer1 |
|---|---|---|
| Hazard ratio (95%CI) | Hazard ratio (95%CI) | |
|
Men and women combined |
|
|
|
Standardized Pi (SD = 0.17) |
0.97 (0.96 – 0.99) |
0.98 (0.96 – 0.99) |
|
Quartiles of Pi (mmol/L) |
|
|
| < 0.95 |
1.00 (Ref) |
1.00 (Ref) |
| 0.95 – 1.05 |
0.98 (0.96 – 1.02) |
1.00 (0.97 – 1.03) |
| 1.05 – 1.16 |
0.94 (0.91 – 0.97) |
0.95 (0.91 – 0.98) |
| ≥ 1.16 |
0.94 (0.91 – 0.97) |
0.95 (0.92 – 0.98) |
| P-value for trend |
< 0.0001 |
< 0.0001 |
|
Men2 |
|
|
|
Standardized Pi (SD = 0.17) |
1.02 (1.00 – 1.04) |
1.02 (1.00 – 1.04) |
|
Quartiles of Pi (mmol/L) |
|
|
| < 0.92 |
1.00 (Ref) |
1.00 (Ref) |
| 0.92 – 1.03 |
1.06 (1.02 – 1.10) |
1.05 (1.01 – 1.09) |
| 1.03 – 1.14 |
1.04 (1.00 – 1.08) |
1.03 (0.98 – 1.08) |
| ≥ 1.14 |
1.07 (1.03 – 1.12) |
1.06 (1.01 – 1.12) |
| P-value for trend |
0.01 |
0.05 |
|
Women2 |
|
|
|
Standardized Pi (SD = 0.16) |
0.97 (0.96 – 0.99) |
0.97 (0.95 – 0.99) |
|
Quartiles of Pi (mmol/L) |
|
|
| < 0.99 |
1.00 (Ref) |
1.00 (Ref) |
| 0.99 – 1.09 |
0.95 (0.91 – 0.99) |
0.98 (0.93 – 1.04) |
| 1.09 – 1.19 |
0.93 (0.89 – 0.97) |
0.93 (0.89 – 0.99) |
| ≥ 1.19 |
0.91 (0.87 – 0.96) |
0.93 (0.88 – 0.98) |
| P-value for trend | < 0.0001 | 0.001 |
All models were adjusted for age, sex, SES, fasting status, calcium, alkaline phosphatase, glucose, creatinine, season, history of diabetes and lung diseases.
1A sensitivity analysis excluding the first three years of follow-up (n = 386,683).
2Not adjusted for sex.