Table 1. Table showing frequency and amplitude of spontaneous IPSCs recorded from mice and rat pyramidal neurons in layers II/III of the frontal cortex.

	Baseline	Nicotine	WY +Nicotine	FBR +Nicotine	WY+MK+Nicotine	FBR+MK+Nicotine
C57BL/6J mice
Frequency, Hz	46.2±1.0	61.2±1.1***	35.1±6.6	40.0±1.6	68.7±12.2*	79.7±16.7*
Amplitude, pA	17.8±0.8	19.8±0.8*	18.3±2.7	18.1±1.6	21.5±1.9*	20.3±1.5*
Rats
Frequency, Hz	15.3±3.2	22.2±4.7***	15.8±11	11.5±0.6	22.5±5.7**	22.5±7.7*
Amplitude, pA	16.4±0.7	21.3±1.5***	13.4±0.8	14.0±1.3	25.1±5.4*	22.8±1.9*

Nicotine (5 µM) significantly increases both frequency and amplitude of sIPSC (*P<0.05, 01, ***P<0.001 vs baseline, paired t-test). Both WY14643 (WY 1 µM) and fenofibrate (FBR, 10 µM) suppressed nicotine’s effects on sIPSCs frequency and amplitude. The PPARα antagonist MK886 restored nicotine’s effects on sIPSC frequency (*P<0.05, **P<0.01 vs baseline, paired t-test).