Figure 1. Among four peptides, Peptide A-8R is strongly cytotoxic to prostate cancer cells.

(A) Four peptides were designed targeting sGCα1, with each peptide containing eight arginines at the C-terminus for membrane translocation. (B) LNCaP cells were grown in 10% serum under different concentrations of the four peptides, as shown. Cell number was measured after 0–4 days of incubation. Data points represent averages of three independent experiments plus standard deviations. Asterisks indicate statistical significance (P<0.0002) of Peptide A activity, relative to Vehicle.