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. 2013 Jun;141(6):691–703. doi: 10.1085/jgp.201210937

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© 2013 Ponissery Saidu et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 6. — Rundown of the Cl⁻ current upon coexpression of ANO2 isoforms. Expression of Isoforms A and B alone and with their respective isoforms lacking exon 4 yielded channels with different rundown properties. (A) Isoform A. (B) Isoform B. (C) Isoform A + A_Δ4. (D) Isoform B + B_Δ4. (E) Rundown as a function of time after patch excision. All currents were normalized to the first current recorded 15 s after excision. *, P < 0.05 for Isoform A compared with A + A_Δ4 at t = 1 min. Number of patches recorded from for Isoform A, B, A + A_Δ4, and B + B_Δ4 were 7, 5, 12, and 7, respectively. The holding potential was −40 mV.