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. 2013 May 27;201(5):693–707. doi: 10.1083/jcb.201302145

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© 2013 Reczek et al.

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Figure 4. — Ctip^S326A/− ES cells are moderately sensitive to CPT- and ETO-induced genotoxic stress. Ctip^+/− and Ctip^S326A/− ES cells were examined for (A) camptothecin (CPT) and (B) etoposide (ETO) sensitivity in clonogenic survival assays, together with ES cells homozygous for the hypomorphic Brca1^Δ223–763 mutation (Brca1^{Δ223–763/Δ223–763}). Cells were exposed for 24 h to varying doses of CPT and ETO, allowed to recover for 7–9 d, and surviving colonies were stained with Crystal violet. Survival is calculated as a percentage of colonies in the mock-treated plates. Each subclone was tested in triplicate, and the error bars represent the SEM of survival for each subclone.