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. 2013 May 27;201(5):693–707. doi: 10.1083/jcb.201302145

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© 2013 Reczek et al.

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Figure 9. — The Brca1–Ctip interaction is not required for tumor suppression. The Kaplan-Meier tumor-free survival curves of the control (Ctip^+/+; blue curve; n = 45; T₅₀ = 750 d) and experimental (Ctip^S326A/S326A and Ctip^S326A/− mice; red curve; n = 40; T₅₀ = 736 d) cohorts are shown. Statistical significance (P = 0.2099) was estimated with the log-rank test using Prism software (version 4; GraphPad Software); values were considered significant at P < 0.05. For comparison, the Kaplan-Meier curve of tumor-prone Brca1^{S1598F/S1598F} mice (purple curve; n = 72; T₅₀ = 575 d; P < 0.0001) is also displayed (Shakya et al., 2011).