Table 1.
Spontaneous and induced chromosomal aberrations in primary MEFs with different Ctip genotypes
| Aberrations | |||||
| Genotype | Metaphases analyzed | MMC treatment | Metaphase aberrations | Chr/Cht breaks and gaps | Exchange/other |
| % | |||||
| Ctip+/+ | 25 | − | 16 | 4 | 0 |
| 25 | + | 44 | 14 | 1 | |
| CtipS326A/S326A clone 1 | 25 | − | 32 | 9 | 0 |
| 25 | + | 52 | 15 | 2 | |
| CtipS326A/S326A clone 2 | 25 | − | 20 | 7 | 0 |
| 25 | + | 52 | 14 | 3 | |
The percentage of metaphases containing one or more aberrations and a breakdown of aberration type is shown for each primary MEF cell line in both the absence (−) and presence (+) of MMC. Cht, chromatid; Chr, chromosome; MMC, mitomycin C.