Table 2.
List of ALS animal models
| Gene | Animal model, mutation | Species | Reference |
|---|---|---|---|
| SOD1 (ALS1) | Transgenic mice of 13 different SOD1 mutant variants are available. | Mouse | (Gurney et al. 1994), and others reviewed in (Bruijn et al. 2004) |
| Transgenic SOD1 mutant variants | Zebrafish | (Lemmens et al. 2007; Ramesh et al. 2010) | |
| Alsin (ALS2) | Alsin KO mouse | Mouse | (Devon et al. 2006) |
| Alsin knock down | Zebrafish | (Gros-Louis et al. 2008) | |
| FUS (ALS6) | Transgenic human WT FUS | Mouse | (Mitchell et al. 2013) |
| Knock down and transgenic mutant FUS | Zebrafish | (Kabashi et al. 2010) | |
| TARDP (TDP43, ALS10) | TARDP Knock out | Mouse | (Kraemer et al. 2010) |
| Transgenic mutant TARDP | Mouse | (Wegorzewska et al. 2009) | |
| Transgenic mutant TARDP | Zebrafish | (Kabashi et al. 2010) | |
| Transgenic mutant TARDP | Rat | (Zhou et al. 2010) | |
| Vps54wr | Wobbler, spontaneous recessive point mutation in vesicular/vacuolar protein sorting 54 | Mouse | (Schmitt-John et al. 2005) |
| Tbcepmn | pmn, spontaneous recessive point mutation in the tubulin-specific chaperone-E | Mouse | (Bommel et al. 2002; Martin et al. 2002) |
| Nefl | Neurofilament light chain overexpressing transgenic mouse | Mouse | (Xu et al. 1993) |
| Nefh | Neurofilament heavy chain overexpressing transgenic mouse | Mouse | (Cote et al. 1993) |
| Prph | Peripherin overexpressing transgenic mouse | Mouse | (Beaulieu et al. 1999) |