Fig. 4.
Comparison of maximum response over time on the Intranasal Tolerability Rating Scale (ITRSa) in the randomized safety population. aITRS was rated on an 11-point scale, ranging from 0 (none) to 10 (worst I can imagine). bLS means from ANCOVA. cDifference of means between treatments from ANCOVA. d90 % CI for difference of means from ANCOVA. e P value for pairwise comparison between treatments from ANCOVA. *P < 0.05 between treatment groups. ANCOVA analysis of covariance, CI confidence interval, ITRS Intranasal Tolerability Rating Scale: ITRS was rated on an 11-point scale, ranging from 0 (none) to 10 (worst I can imagine), LS least squares, OC-F finely crushed original formulation of oxycodone-HCl controlled release, ORF-C coarsely crushed reformulated oxycodone-HCl controlled release, ORF-F finely crushed reformulated oxycodone-HCl controlled release