Table 2.

Treatment comparisons of pharmacokinetic metrics

Parameter		ORF-C vs ORF-F	ORF-F vs OC-F	ORF-C vs OC-F
C max (ng/mL)	Mean ratio of PK metric (90 % CI)	86.3 (76.91, 96.78)	77.6 (69.27, 87.02)	67.0 (59.76, 75.07)
AUC∞ (ng·h/mL)	Mean ratio of PK metric (90 % CI)	103.0 (91.64, 116.10)	97.4 (86.56, 109.50)	100.0 (89.29, 112.94)

Treatment groups were ORF-C 10 mg (n = 29), ORF-F (n = 29), and OC-F 10 mg (n = 30)

AUC _∞ area under the plasma concentration-time curve extrapolated to infinity; CI confidence interval, C _max maximum observed plasma concentration, OC-F finely crushed original formulation of oxycodone HCl controlled release, ORF-C coarsely crushed reformulated oxycodone HCl controlled release, ORF-F finely crushed reformulated oxycodone HCl controlled release, PK pharmacokinetic