. 2012 Jul 15;22(5):1123–1133. doi: 10.1007/s11136-012-0230-7

Table 6.

Responsiveness: average change in Migraine-Specific Questionnaire scale scores in relation to changes in number of headache days from baseline to week 24

Percentage improvement in headache frequency	n	Mean change in MSQ	SD	SRM	F value^a	p Value^a	F value^b	p Value^b
Role restrictive
Study 1 (%)
≥50	234	23.3	24.0	1.0	63.5	<0.001	63.4	<0.001
≥30 to <50	107	12.6	20.1	0.6
<30	244	3.0	14.0	0.2
Study 2 (%)
≥50	269	23.1	22.4	1.0	72.9	<0.001	71.2	<0.001
≥30 to <50	116	10.6	21.8	0.5
<30	262	2.7	15.0	0.2
Role preventive
Study 1 (%)
≥50	234	18.5	22.2	0.8	45.4	<0.001	45.3	<0.001
≥30 to <50	107	11.2	19.0	0.6
<30	243	1.7	16.4	0.1
Study 2 (%)
≥50	269	18.4	22.8	0.8	54.9	<0.001	55.4	<0.001
≥30 to <50	116	8.5	20.1	0.4
<30	262	0.4	16.1	0.0
Emotional function
Study 1 (%)
≥50	233	24.6	27.91	0.88	50.7	<0.001	50.6	<0.001
≥30 to <50	105	14.9	23.56	0.63
<30	243	2.2	20.58	0.11
Study 2 (%)
≥50	269	26.8	26.34	1.02	74.6	<0.001	73.9	<0.001
≥30 to <50	116	11.0	24.84	0.44
<30	261	1.8	19.97	0.09

Percentage improvement in 28-day frequency of headache days was evaluated as

\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$ \frac{{({\text{frequency}}\;{\text{at}}\;{\text{week}}\;24-{\text{frequency}}\;{\text{at}}\;{\text{baseline}})}}{{{\text{frequency}}\;{\text{at}}\;{\text{baseline}}}} \times 100 $$\end{document}

MSQ Migraine-Specific Questionnaire, SD standard deviation, SRM standardized response mean

^a F statistics and p values for between-category comparisons are from analysis of variance (ANOVA). The main effect in the ANOVA was ranked category of decrease in number of headache days, where the type III sum of squares was used

^b F statistics and p values for between-category comparisons are from analysis of variance (ANOVA). The main effects in the ANOVA included ranked category of decrease in number of headache days and medication-overuse strata, where the type III sum of squares was used