Figure 5.

Schematic representation of modular exon structure of the eight functional NR1 splice variants. Absence of (1–4A) or presence of (1–4B) of a 21 amino acid sequence close to the N-terminal region also illustrated. The length of the mature protein is given in amino acid (aa) in right side. There are three different deletions at the C-terminal end. Exon 5 (63 bp), exon 21 (111 bp) featuring an ER retention signal, exon 22 (356 bp), 22′ alternative C-terminal (66 bp) featuring a divalent motif for enhanced ER export. Trans membrane domain (TM 1–4) are shown in white box. [Adapted and modified from Hynd et al. (2004)].