Table 3.
Type of modification | Enzymes | Target gene transcription | Ethanol effect |
---|---|---|---|
ACETYLATION | |||
H3 K9 | GNAT | Activating | Increase |
H3 K14 or K18 or K23 | MYST | Activating | Non-detected |
H3 and H4 | CBP/p300 | Activating | Increase |
DEACETYLATION | |||
H3 H4 | HDACs1–11 | Activating | Ethanol up-regulated genes |
H3 K9 | SUV39H1 | Silencing | Ethanol down-regulated genes |
METHYLATION | |||
H3 K4 | Set1 | Activating | Ethanol up-regulated genes |
H3K36 | Set2 | Activating | Ethanol up-regulated genes |
H3K79 | DoT1L | Activating | Ethanol up-regulated genes |
H3K27 | EZH2 | Silencing | Non-detected |
H4K20 | SUV4-20H1 | Silencing | Non-detected |
Methylated CpG | DNMT1, DNMT3a-3b | Decrease activity | Ethanol down-regulated genes |
PHOSPHORYLATION | |||
H3 S10 | RSK2 | Not known | Increase |
H3 S28 | – | Not known | Increase |