Synaptic plasticity |
Histone acetylation |
Rat, hippocampus |
ERK/MAK activity leads to H3K14 hyper-acetylation |
Levenson et al., 2004
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Rat, amygdala |
TSA increases LTP |
Yeh et al., 2004
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Rat, hippocampus |
PKC activation enhances LTP and H3K14 acetylation |
Miller et al., 2008
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Mouse, hippocampus |
CBP deficiency result in H2B hypo acetylation |
Alarcon et al., 2004
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Mouse, hippocampus |
TSA enhances LTP and transcription of CRE |
Vecsey et al., 2007
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Mouse, hippocampus |
HDAC2 overexpression impairs, HDAC2 k.o |
Guan et al., 2009
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Mouse, hippocampus |
PcGprotein MII-deficiency enhances, TrxG protein and EED deficiency impairs LTP |
Kim et al., 2007
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DNA methylation |
Mouse, hippocampus |
MBD1 deficiency leads to reduced LTP |
Zhao et al., 2003
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Mouse, hippocampus |
Inhibition of DNMT1 activity by 5-aza blocks LTP |
Levenson et al., 2006
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Mouse, hippocampus |
5-Aza and zebularine reduce mEPSCs and increase BDNF DNA methylation and transcription |
Nelson et al., 2008
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Mouse, forebrain |
Double knock-out DNMT1 and DNMT3a impairs Synaptic plasticity |
Feng et al., 2010
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Seizures |
Histone acetylation |
Rat, hippocampus |
Pilocarpine-induced seizures leads to H4 hypo acetylation of GluR2 |
Huang et al., 2002
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Rat, hippocampus |
Acute and chronic electroconvulsive seizures induce differential H3 and H4 acetylation |
Tsankova et al., 2004
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Schizophrenia |
DNA methylation |
Human post-mortem brain, cortex region |
GAD67 and SOX10 promoter region are hyper methylated correlating with reduced mRNA level |
Iwamoto et al., 2005; Guidotti et al., 2007; Huang and Akbarian, 2007
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Human post-mortem brain, frontal lobe |
COMT promoter is hypo methylated correlating with increased mRNA levels |
Abdolmaleky et al., 2006
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ATRXS |
DNA methylation |
Human patient-derived cell lines |
Mutations in ATRX result in aberrant DNA methylation |
Gibbons et al., 2000
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Mouse, forebrain |
ATRX form a silencing complex with MeCP2 that is disturbed in ATRXS |
Kernohan et al., 2010
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Rett syndrome |
DNA methylation |
Human lymphocytes mouse, hippocampus, cortex and cerebellum |
MeCP2 mutations lead to reduced and CpG islands and acts a transcriptional repressor |
Amir et al., 1999; Chen et al., 2001; Collins et al., 2004
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DNA methylation and histone acetylation |
Mouse, cortex, cerebellum murine cells lines |
MeCP2 mutations cause aberrant transcriptionally permissive |
Shahbazian et al., 2002; Martinowich et al., 2003
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Histone acetylation and methylation marks |
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Rubinstein Taybi Syndrome |
Histone acetylation |
Mouse, hippocampus |
Reduced global HAT activity due to loss of function in CBP |
Oike et al., 1999; Alarcon et al., 2004; Korzus et al., 2004
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Fragile X mental retardation |
DNA methylation |
Human and mouse cell lines |
Expansion of CGG or CCG repeats results in aberrant DNA methylation around FMR1 and FMR2 genes |
Ashley et al., 1993; Chiurazzi et al., 1998
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Alzheimer's |
Histone acetylation |
Human and mouse cell lines |
APP intracellular domain acts as a Notch-like transcription factor associated with HAT TIP60 |
Herman et al., 2006; Haberland et al., 2009
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Contextual memory Visual cortical plasticity |
Histone acetylation/phosphorylation |
Crab, central brain |
Contextual training increased H3 acetylation |
Federman et al., 2009
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Mouse, visual cortex region |
Visual stimulation increases H3 phosphoacetylation via ERK/MAPK |
Putignano et al., 2007
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Object memory |
Histone acetylation |
Mouse, hippocampus, forebrain |
CBP and p300 deficient mouse have impaired long-term object memory |
Alarcon et al., 2004
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Histone acetylation/methylation |
Muse, hippocampus |
Estradiol enhances object memory and increases H3K14 but not H4acetylation |
Oliveira et al., 2007; Zhao et al., 2010
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Nuclear inhibition of PP1 increases object memory as well as |
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Mouse, hippocampus |
H3K14/H4K5 acetylation, H3K36 trimethylation and H3S100 phosphorylation |
Koshibu et al., 2009
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Fear memory |
Histone acetylation |
Rat, hippocampus |
ERK/MAPK activation increases contextual fear memory and H3 |
Chwang et al., 2006
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DNA methylation |
Mouse, hippocampus |
VPA and SB rescue and H3 and H4 hyperacetylation |
Dash et al., 2009
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Mouse, hippocampus |
CBP deficiency impairs contextual fear conditioning |
Wood et al., 2005
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Rat, hippocampus |
Contextual feat training increases BDNF expression and reduce its promoter methylation |
Lubin et al., 2008
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Spatial memory |
Histone acetylation |
Mouse, hippocampus |
CBP deficiency impairs spatial memory accompanied by H2B hypo acetylation. |
Alarcon et al., 2004; Korzus et al., 2004
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Acetylation/methylation/phosphorylation |
Mouse, hippocampus |
Nuclear inhibition of PP1 increases spatial memory as well as H3K13/H4K5 acetylation, H3K36 tri-methylation and H3S100 phosphorylation |
Koshibu et al., 2009
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Taste memory |
Histone acetylation |
Mouse, insular cortex |
TSA increases H2A and H4 acetylation in brain areas important for taste memories |
Swank and Sweatt, 2001
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