Table 1.

Illustrated here is the presence or absence of HtrA-1 and TGF-β1 in both wild type (WT) and RAGE KO samples as indicated by immunohistochemistry.

Mouse	HtrA-1	TGF-β1
RAGE KO 1	+	−
RAGE KO 2	+	−
RAGE KO 3	+	−
RAGE KO 4	−	+
RAGE KO 5	+	−
WT 1	+	−
WT 2	+	−
WT 3*	+	+
WT 4	+	−
WT 5	−	+
WT 6	+	−

^*Indicates the only exception to the observed trend.

A significant trend was observed between the presence of HtrA-1 and TGF-β1 in both the RAGE KO and wild type samples. With the exception of WT 3, all samples demonstrated a trend where samples which stained positive for HtrA-1 consistently stained negative for TGF-β1, while samples which stained negative for HtrA-1 consistently stained positive for TGF-β1. The statistical significance of this pattern was tested using a Chi-Squared test and was found to be highly significant (p < 0.01).