Figure 4.

LIG4 Syndrome Mutations in the Structure of LigIV^1–609

(A) Map of residues related to LIG4 syndrome. Residues, mutations of which cause LIG4 syndrome, are shown in a stick representation and magenta. The residues after R580 and R588 are colored in yellow and orange.

(B) Mutation T9I. I9 (gray) is superimposed onto T9 (magenta). S12 and Q146 are residues having hydrogen bonds with T9. The Artemis peptide is shown in a cartoon representation.

(C) Mutation M249V. V249 (gray) is superimposed onto M249 (magenta).

(D) Mutation G469E. E469 (gray) is superimposed on G469.