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. Author manuscript; available in PMC: 2014 Jun 21.
Published in final edited form as: Phys Chem Chem Phys. 2013 Apr 24;15(23):8952–8961. doi: 10.1039/c3cp50721a

Figure 3.

Figure 3

(A) IM-MS data for Aβ1-40 (20 μM) incubated with LE (60 μM) for 1 h on ice, where Aβ:LE complexes are labeled, along with free peptide. IM separation allows for the identification of Aβ dimer complexes previously undetected by MS alone. Aβ1-40 is seen in complex with LE at stoichiometric ratios up to 1:3 Aβ1-40:LE and 2:3 Aβ1-40:LE. (B) MS dataset for the IM-MS plot shown in A. (C) Two main conformations of Aβ1-404+ are identified, with a third minor conformer, as observed previously.29 (D) A magnified region of the IM-MS data shown in A, showing detail on Aβ1-404+: LE complexes. Monomer complexes are observed in greater relative abundance than those related to dimeric Aβ.