Figure 3.
CCR1 expression by both BM and non-BM-derived cells promotes tumor metastasis. Survival curve of CCR1-/- and control chimeric mice injected IV with 5 x 105 EL-4. Chimeric mice resulted from control and CCR1-/- irradiated hosts reconstituted with CCR1-/- GFP or control GFP BM. CCR1-/- hosts with control BM (open squares; n = 7) and WT host with control BM (filled squares; n = 9) had significantly decreased mean survival than mice of the same genotype with CCR1 BM, respectively, WT host with CCR1 BM (open circles; n = 10) and CCR1 host with CCR1 BM (filled circles; n = 11 mice).