Table 3.
The raw p-values of the most significant haplotypes formed from 247 fine-mapping SNPs spanning chr16:25727220-43876419.
| Sex as a Covariate3 | Sex and Raced as Covariates4 | |||||
|---|---|---|---|---|---|---|
| Haplotype Position1 | SNPs2 | Pop 1 | Pop 2 | All | Pop 1 | All |
| chr16.28806500-28896478 | 4 | 8.8 × 10−3 (2.05) | 2.7 × 10−4 (3.56) | 1.1 × 10−4 (3.95) | 8.5 × 10−3 (2.07) | 1.4 × 10−4 (3.86) |
| chr16.29228158-29334863 | 6 | 1.8 × 10−4 (3.75) | 5.5 × 10−2 (1.26) | 1.4 × 10−4 (3.86) | 4.6 × 10−4 (3.34) | 9.4 × 10−5 (4.03) |
| chr16.29854244-29937753 | 4 | 2.2 × 10−3 (2.66) | 1.3 × 10−1 (0.89) | 3.7 × 10−3 (2.44) | 1.2 × 10−3 (2.93) | 4.6 × 10−3 (2.34) |
| chr16.30375999-30637486 | 5 | 8.7 × 10−3 (2.06) | 2.2 × 10−3 (2.65) | 8.9 × 10−5 (4.05) | 2.0 × 10−3 (2.71) | 8.5 × 10−5 (4.07) |
| chr16.30489154-30817982 | 12 | 1.3 × 10−2 (1.88) | 5.9 × 10−4 (3.23) | 3.4 × 10−5 (4.47) | 5.0 × 10−3 (2.31) | 3.8 × 10−5 (4.42) |
| chr16.31808864-31859044 | 4 | 6.9 × 10−4 (3.16) | 2.9 × 10−2 (1.53) | 1.8 × 10−4 (3.74) | 9.6 × 10−4 (3.02) | 1.8 × 10−4 (3.75) |
| chr16.31924094-32234376* | 8 | 4.4 × 10−3 (2.36) | 7.3 × 10−2 (1.14) | 2.8 × 10−4 (3.55) | 1.9 × 10−3 (2.73) | 2.0 × 10−4 (3.69) |
| chr16.32255697-32407166 | 9 | 2.6 × 10−3 (2.59) | 3.7 × 10−2 (1.43) | 6.7 × 10−5 (4.18) | 1.2 × 10−2 (1.91) | 2.4 × 10−5 (4.62) |
| chr16.32381149-32550636 | 7 | 1.2 × 10−2 (1.93) | 2.6 × 10−2 (1.59) | 3.4 × 10−5 (4.47) | 2.4 × 10−2 (1.62) | 2.1 × 10−5 (4.68) |
| chr16.32880400-32980666 | 5 | 4.5 × 10−3 (2.35) | 0.25 (0.60) | 3.5 × 10−3 (2.46) | 1.2 × 10−3 (2.93) | 3.4 × 10−3 (2.47) |
| chr16.36970325-37536110 | 7 | 4.2 × 10−3 (2.38) | 3.0 × 10−1 (0.52) | 4.4 × 10−2 (1.36) | 1.1 × 10−5 (4.95) | 3.3 × 10−2 (1.49) |
| chr16.41947080-42152983 | 6 | 2.1 × 10−4 (3.68) | 6.6 × 10−3 (2.18) | 2.2 × 10−4 (3.66) | 3.5 × 10−5 (4.46) | 3.3 × 10−4 (3.48) |
| chr16.41947080-42340193 | 8 | 5.4 × 10−3 (2.27) | 2.4 × 10−2 (1.62) | 7.9 × 10−4 (3.10) | 5.8 × 10−4 (3.24) | 1.3 × 10−3 (2.87) |
1
Boundaries of the haplotype on chromosome 16.
2
Number of SNPs within the haplotype.
3
The p-values (negative log p-values are adjacently listed in parentheses) after additive logistic regression with gender as a covariate for population 1, population 2, and both populations together.
4
The p-values (negative log p-values are adjacently listed in parentheses) after additive logistic regression with gender and racing history as covariates for population 1 and both populations together.
*
Position chr16.31924094-32234376 has the same significance as chr16.31943558-32234376