Figure 2. Phosphorylation sites at the kinetochore.
A comparison of known phosphorylations present at the kinetochore of a chromosome before (top panel) and after (bottom panel) achieving bioriented microtubule attachments. The unattached kinetochore is generating the spindle assembly checkpoint (SAC) cell cycle arrest via formation of the mitotic checkpoint complex (MCC). The color and letter within each phosphorylation (star shapes) correspond to the kinase responsible (see legend, top). Question marks in the lower panel denote phosphorylations that may be retained upon borientation but for which more information is required.