Table 1.
Physiochemical characterization of in situ gels of Voriconazole, mean ± SD; n = 3.
| Formulations | Concentration | Gelation temperature (°C) | Drug content % |
pH | |
|---|---|---|---|---|---|
| *PF-68 | *Na alginate | ||||
| VG1 | 14 | 0.5 | 37.33 ± 0.73 | 96.98 ± 1.34 | 6.8 |
| VG2 | 14 | 1 | 36.50 ± 0.35 | 96.34 ± 2.00 | 6.9 |
| VG3 | 14 | 1.5 | 35.70 ± 0.36 | 93.33 ± 1.26 | 7.0 |
| VG4 | 15 | 0.5 | 33.80 ± 0.40 | 92.34 ± 2.15 | 6.9 |
| VG5 | 15 | 1 | 32.60 ± 0.30 | 94.91 ± 0.372 | 7.1 |
| VG6 | 15 | 1.5 | 30.83 ± 0.65 | 99.01 ± 2.79 | 7.4 |
| VG7 | 16 | 0.5 | 29.63 ± 0.51 | 97.09 ± 1.90 | 6.9 |
| VG8 | 16 | 1 | 28.36 ± 0.41 | 92.34 ± 0.66 | 6.8 |
| VG9 | 16 | 1.5 | 24.36 ± 0.41 | 91.41 ± 0.51 | 7.2 |
*PF 68—Pluronic 68 or Poloxamer 118.
*Na alginate—sodium alginate.