Table 1.

Six metabolites of YZP detected in vivo from the previous experiment.

No.	RT (min)	[M + H]+	Formula	Metabolite name	Formula change	Parent compound	Source
M1	4.1880	342.1333	C19H19NO5	Demethylation, hydrogenation	−CH2+H2	Protopine	Plasma
M2	9.08278	342.1691	C20H23NO4	Demethylation	−CH2	Tetrahydropalmatine	Plasma
M3	10.6147	342.1695	C20H23NO4	Demethylation	−CH2	Tetrahydropalmatine	Plasma, CSF
M4	21.8366	301.0715	C16H12O6	Methylene to ketone	+O–H2	Oxypeucedanin	Plasma
M5	5.21887	326.1384	C19H19NO4	Demethylation	−CH2	Tetrahydroberberine	Plasma, CSF
M6	8.0093	326.1386	C19H19NO4	Demethylation	−CH2	Tetrahydroberberine	Plasma

CSF: cerebrospinal fluid.