. 2013 May 14;53(5):1100–1112. doi: 10.1021/ci400100c

Table 2. Biochemical Assay Results IC₅₀ and Ligand Efficiencies (LE) for Compounds Derived from the Whole Molecule Virtual Screen, with ≥50% Inhibition at 40 or 400 μM^a.

graphic file with name ci-2013-00100c_0009.jpg

ND = not determined.

^†

Single point assays were performed in duplicate; percent inhibition values shown are the mean of the two results reported with the standard deviation.

^‡

IC₅₀ experiments were performed in duplicate on the same assay plate at 1% and 10% DMSO. An asterisk indicates compounds tested at 10% DMSO; all other compounds were tested at 1% DMSO.

^⊥

Percent inhibition and IC₅₀ values do not correlate for these compounds due to poor solubility at higher concentrations.

Table 2. Biochemical Assay Results IC50 and Ligand Efficiencies (LE) for Compounds Derived from the Whole Molecule Virtual Screen, with ≥50% Inhibition at 40 or 400 μMa.

Table 2. Biochemical Assay Results IC₅₀ and Ligand Efficiencies (LE) for Compounds Derived from the Whole Molecule Virtual Screen, with ≥50% Inhibition at 40 or 400 μM^a.