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Viability of adipose-derived, mesenchymal stem cells in 1%, 2%, and 20% O2 with and without the HIF-1 inhibitor in (A) 2-D and (B) 3-D culture conditions over a period of 4 weeks. The values shown represent the mean±standard deviation from three independent experiments. When a statistically significant difference (p<0.05) is observed between 20% O2 in comparison to 1% and 2% O2, it is marked (*) for both 2-D and 3-D studies.
