FIG. 5.

VergenixFG induces early angiogenesis and reduces inflammatory response in a pig wound model. Full-thickness cutaneous wounds were created on the backs of two domestic pigs and then treated with either rhCollagen flowable gel or commercially available bovine collagen flowable matrix. Wounds were clinically evaluated for inflammatory response, and samples were harvested on days 7 and 21 for microscopical analysis of inflammatory and angiogenesis responses. Sections were stained with either H&E or anti-vWF antibody for determination of blood vessel formation, and then scored. (n=10 for Control, n=14 for Test until day 7, n=5 for Control, and n=7 for Test until day 21). (A) Blood vessel formation scores (*p<0.05). (B) Representative images of blood vessel formation immunohistochemistry. (C) Foreign body responses in VergenixFG-treated versus bovine collagen matrix-treated wounds. (D) Clinical wound assessment of inflammation of VergenixFG-treated versus bovine collagen matrix-treated wounds. Color images available online at www.liebertpub.com/tea