FIG. 5.

The GAG mimetic [OTR₄₁₂₀] immobilized on the TCP/HA substitutes potentiates the in vivo vascularization of the devices. (A) Macroscopic views of the capillary network surrounding each series of constructs. White bar: 5 mm. (B, C) Automatic computerized vessel tree segmentation decomposed the capillary areas in a sum of objects discriminating intermediary (segments) and terminal (branches) degrees of ramification before (B) and after (C) modelization. Black scale bar: 2 mm. (D) Automatic computerized quantification of the vascular element number. Data are mean values±SD from n=12 samples (4 cardinal areas per scaffold×2 scaffolds per mice×2 mice per conditions×2 independent experiments; *p<0.05; **p<0.01). Color images available online at www.liebertpub.com/tea