Table 3.

Classification of Adverse Events in Children With Drug-Resistant Tuberculosis

	Recommended Term	Definition
Adverse drug events	Clinical	DMID grading scale 0–4 [35]
	Laboratory	DMID grading scale 0–4 [35]
	Arthralgia/arthritis	Not covered but parallels with DMID Grade 0 – No pain Grade 1 – Pain, but no interference with function or movement Grade 2 – Moderate pain affecting function, but able to carry out normal activities Grade 3 – Severe pain limiting activities Grade 4 – Disabling pain and unable to carry out normal activities
	Thyroid function	Abnormal considered if TSH raised above and T4 below the threshold of normal, using the reference ranges that have been specified by the laboratory with consideration of the analyzer used and the age of the child
	Hearing	ASHA criteria for hearing loss [50-52] using pure tone audiometry. Hearing loss defined as a change from baseline of the following: 20 decibel decrease at any 1 frequency or 10 decibel decrease at any 2 adjacent frequencies or Loss of response at 3 consecutive test frequencies where responses were previously obtained.

Abbreviations: ASHA, American Speech and Hearing Association; DMID, Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, US National Institutes of Health; TSH, thyroid-stimulating hormone.