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The Sigma-1 receptor (S1R) in degenerating motoneurons of SOD*G93A mice in the late disease stages. The S1R remained localized in C-terminals and is expressed at high levels. The Sigma-1 receptor is green and the Kv2.1 channel (marker of C-terminals) is red. Blue is DAPI nuclear stain. Single motoneurons in the white frame are shown at higher magnification in the lower panel. Scale bar= 20um.
