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. Author manuscript; available in PMC: 2013 May 28.
Published in final edited form as: Pharmacol Ther. 2012 May 11;135(2):151–167. doi: 10.1016/j.pharmthera.2012.05.003

Fig. 8.

Fig. 8

The three components of the glycine deportation system. 1. Glycine (Gly) is deported from the liver as hippuric acid (BAGly) by the hepatic glycine deportation system (GDSL) that uses benzoic acid (BA), coenzyme A (CoA) and 2 mol ATP. 2. Gly is also deported from the kidney as BAGly by the kidney glycine deportation system (GDSK) that also requires BA, CoA, and 2 mol ATP. This system can also use salicylic acid (SA), deporting Gly as salicyluric acid (SAGly). 3. BAGly (and SAGly) are subjected to active tubular secretion in the final stage of glycine urinary deportation.