Table 2.
Agent | No. of monkeysa) | Route | Daily dose (mg/kg) | No. of dead with malignant tumor | Carcinogenicity |
---|---|---|---|---|---|
Doxorubicin hydrochloride | 10 | iv | 0.2 | 0 | no |
Doxorubicin hydrochloride | 10 | iv | 0.4 | 1 | no |
Doxorubicin hydrochloride | 10 | iv | 1.0 | 1 | no |
Cyclophosphamide | 23 | po | 6.0 | 1 | not conclusive |
Melphalan | 20 | ng | 0.1 | 2 | not conclusive |
Procarbazine | 49 | sc/po, ip/po, or ip | 10 | 17 | yes |
MNU | 43b) or 44c) | po | 10 | 18 | yes |