Table 6.
Tumorigenicity in humans, nonhuman primates and rodents
| Agents | Human (IARC Evaluation) | Nonhuman primates | Rodents |
|---|---|---|---|
| Doxorubicin hydrochloride | Probably yes (2A) | not conclusive | yes |
| Cyclophosphamide | yes (1) | not conclusive | yes |
| Merphalan | Possibly yes (2B) | not conclusive | yes |
| Procarbazine | yes (1) | yes | yes |
| MNU | Probably yes (2A) | yes | yes |
| Saccharin | no | no | yes |
| Cyclamate | no | no | yes |
| DDT | yes (2B) | not conclusive | yes |
| IQ | Probably yes (2A) | yes | yes |
| MeIQx | Possibly yes (2B) | no | yes |
| PhIP | Possibly yes (2B) | no | yes |
| 4-Dimethylamino-azobenzene | Possibly yes (2B) | no | yes |
| 2-Acethylamino-fluorene | not available | no | yes |
| 2,7-Bisacethylamino-fluorene | not available | no | yes |
| 3-MC | not available | no | yes |