Table 1.

Selectivity of DAG-indololactones for PKC alpha versus RasGRP3

Compound	PKC α Ki, nMb	RasGRP3 Ki, nMb	Ratio PKC α/RasGRP3	Slog Pc
1	49.1 ± 5.9a	0.41 ± 0.01a	120	4.36
2	10.9 ± 1.5	0.25 ± 0.02	43.6	3.99
3	32.0 ± 2.9	1.3 ± 0.1	24.6	4.36

^aValues derived in experiments done in parallel. See El Kazzouli^[12] for initial characterization of this compound.

^bValues represent the mean ± SEM of three or more independent dose response curves.

^cSlogP calculations^[17]