Table 2.
Labeling index (LI) in relation to grades of CIN and stages of invasive cervical carcinoma
| Type | Grade/stage | No | TK1 total* | P | TK1 cyto + nucl** | P | Ki-67 | P |
|---|---|---|---|---|---|---|---|---|
| CIN |
Grade I |
78 |
17.5±16.7 |
|
7.3±11.2 |
|
10.8±13.0 |
|
| |
|
|
|
<0.0001 |
|
<0.0001 |
|
<0.0001 |
| |
Grade II |
64 |
37.2±22.9 |
|
22.1±18.7 |
|
26.5±21.2 |
|
| |
|
|
|
<0.0001 |
|
<0.0001 |
|
<0.0001 |
|
Carcinoma in situ |
Grade III |
74 |
54.6±20.5 |
|
36.6±18.9 |
|
43.9±23.1 |
|
| (CIN III) | ||||||||
| |
|
|
|
0.001 |
|
0.041 |
|
<0.0001 |
| Invasive CA |
Stage II |
50 |
66.6±17.8 |
|
43.5±18.4 |
|
60.5±23.1 |
|
| |
|
|
|
0.029 |
|
0.117 |
|
0.701 |
| Stage III | 34 | 74.9±15.4 | 49.7±18.4 | 62.5±23.2 |
*TK1 expression in cytoplasm alone + TK1 expression in both cytoplasm and nuclear; ** TK1 expression in cytoplasm + nuclear; No = number of patients. CA = carcinoma.