Table 2.

NRAS and BRAF genotypes in familial melanomas harboring CDKN2A germline mutations

Tumor number	CDKN2A mutation		NRAS mutation		BRAF mutation
	Protein change	Base change	Protein change	Base change	Protein change	Base change
1	p.A4_P11del	c.9_32del24	WT‡	none	p.V600E	c.1799T>A
2	p.A4_P11dup	c.32_33dup9-32	WT	none	WT	none
3	p.A4_P11 dup	c.32_33 dup9-32	WT	none	WT	none
4	p.A4_P11 dup	c.32_33 dup9-32	WT	none	WT	none
5	p.L16P	c.47T>C	WT	none	WT	none
6	p.L16P	c.47T>C	WT	none	WT	none
7	p.R24P	c.71G>C	WT	none	WT	none
8	p.R24P	c.71G>C	WT	none	p.V600E	c.1799T>A
9	p.R24P	c.71G>C	WT	none	p.V600E	c.1799T>A
10	p.L32P	c.95T>C	p.Q61K	c.181C>A	p.V600E	c.1799T>A
11	p.L32P	c.95T>C	p.Q61R	c.182A>G	p.V600E	c.1799T>A
12	p.L32P*	c.95T>C	p.Q61K	c.181C>A	p.V600E	c.1799T>A
13	p.L32P*	c.95T>C	WT	none	WT	none
14	p.G35A	c.104G>C	WT	none	WT	none
15	p.G35A	c.104G>C	WT	none	p.V600E	c.1799T>A
16	p.M53I	c.159G>C	WT	none	WT	none
17	p.G101W†	c.301G>T	WT	none	WT	none
18	p.G101W†	c.301G>T	WT	none	WT	none
19	p.G101W†	c.301G>T	WT	none	WT	none
Total: 19			3 (16%)		7 (37%)

^*Samples originating from the same patient

^†Samples originating from Genoa

^‡Wild type