Table 3.
Problems and concerns patients attribute to opioid use by average daily dose (weighted estimates)
| Opioid Morphine Equivalent Daily Dose | |||||
|---|---|---|---|---|---|
| 1-19mg | 20-49mg | 50-119mg | 120+mg | p-value a | |
| Psychosocial Problems | |||||
| Loss of interest in activities, % | 4.9 | 9.6 | 8.0 | 14.6 | 0.01 |
| Trouble concentrating, % | 6.5 | 15.6 | 17.2 | 24.0 | 0.04 |
| Feeling slowed down, sluggish, % | 14.8 | 15.7 | 18.0 | 25.1 | 0.03 |
| Feeling depressed, anxious, % | 4.0 | 7.8 | 8.2 | 15.1 | 0.0004 |
| Interference with work, family social activities, % |
10.8 | 16.9 | 22.9 | 32.2 | <.0001 |
| Hard to think clearly, % | 8.6 | 14.6 | 17.1 | 24.2 | 0.15 |
| Less alert when driving or other activity require vigilance, % |
20.8 | 28.7 | 35.8 | 45.4 | 0.007 |
| Control Concerns | |||||
| Preoccupied with opioids, % | 5.0 | 10.1 | 7.2 | 9.2 | 0.24 |
| Concern about control over use, % | 2.8 | 4.7 | 5.4 | 8.0 | 0.63 |
| Need higher dose for same effect, % | 19.5 | 24.8 | 34.6 | 41.5 | <.0001 |
| Worry about opioid dependence, % | 17.2 | 30.1 | 37.4 | 46.8 | <.0001 |
| Want to stop or cut-down on opioids, % |
33.9 | 44.5 | 50.3 | 51.5 | 0.01 |
| Opioids caused family problems, % | 1.7 | 4.5 | 7.4 | 10.7 | 0.046 |
| Family or friends thought might be addicted to opioids, % |
5.8 | 11.0 | 18.2 | 24.9 | <.0001 |
a
p-value for opioid dose adjusted for health plan and opioid type.