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Selective inhibitors recently discovered by competitive ABPP
| Target | Compound | Structure | Ref. | Potential Indication(s) |
|---|---|---|---|---|
| AADACL1 | AS115 |
|
173 | cancer |
| JW480 |
|
174 | ||
| ABHD6 | WWL123 |
|
11 | unknown |
| ABHD11 | AA44-2 |
|
14 | unknown |
| WWL222 |
|
11 | ||
| APEH | AA74-1 |
|
14 | unknown |
| MGLL | JZL184 |
|
78 | cancer, pain |
| PAFAH2 | AA39-2 |
|
14 | unknown |
| PME-1 | ABL127 |
|
189 | cancer, Alzheimer’s disease |
The electrophilic moieties of each compound are colored red.
