Table 4.

Multi-species domain hotspots

	Domain Hotspot Count (1.6)	Domain Hotspot count (1.3)	Domain Hotspot Count (1.0)
Total multi-species position-based domain hotspots	861	1,078	1,331
Total multi-species feature-based domain hotspots	4,243	4,809	5,439
Multi-species position-based domain hotspots not identified in yeast or human	143	187	238
Multi-species feature-based domain hotspots not identified in yeast or human	1,243	1,533	1,672

Position-based and feature-based domain hotspots identified by applying the DS-Score to a combined set of yeast and human mutations. This table shows the number of multi-species domain hotspots we can identify at each threshold, as well as the number of domain hotspots that were not previously identified when analyzing mutations from only yeast or only human.