Table 5.

Mapping of domain hotspots from yeast to known disease mutations in human.

	Domain Hotspot Count (1.6)	Domain Hotspot count (1.3)	Domain Hotspot Count (1.0)
Position-based domain hotspots in yeast	101	114	135
Feature-based domain hotspots in yeast	791	869	1,022
Position-based domain hotspots in yeast that hit at least one human mutation	54 (53.5%, p-value: 2e-26)	56 (49.1%, p-value: 6e-25)	65 (48.8%, p-value: 5e-28)
Feature-based domain hotspots in yeast that hit at least one human mutation	562 (71.1%, p-value ≈ 0)	592 (68.1%, p-value ≈ 0)	666 (65.2%, p-value ≈ 0)

Position-based and feature-based hotspots from yeast that could be associated with a human mutation through a common protein domain position were quantified (P-values from Fisher exact test are shown).