Table 6.
Selected functional feature sites containing domain hotspots in yeast and human
| Functional Feature Name | Position-based Domain Hotspots in Yeast | Position-based Domain Hotspots inHuman |
|---|---|---|
| ABC transporter signature motif | 1 | 2 |
| Activation loop (A-loop) | 4 | 99 |
| Active site | 28 | 32 |
| ATP binding site | 19 | 13 |
| Ca2+ binding site | 1 | 2 |
| GTP/Mg2+ binding site | 3 | 7 |
| G1 box | 3 | 6 |
| Substrate binding site | 5 | 17 |
Functional features found to contain position-based hotspots in human and yeast (using a DS-Score threshold of 1.3 to define the domain hotspots).