Figure 7. Long-lived resistance against ECM in 3-cure mice.

After challenge infection, 3-cure mice fully recovered with clearance of parasitemia around day 21 PI. They were regularly examined at 3-month intervals and showed no parasitemia. Twelve and twenty months post the last challenge infection, these aged 3-cure mice were re-challenged with 10⁴ of homologous PbA-pRBCs. The age-matched B6 mice were used as control. (A) Survival curves and (B) Parasitemia profile. Data presented are from one experiment with three to five mice in each group. Statistic significance between 0-cure and 3-cure was performed by using log-rank test and Mann-Whitney U test, where NS, p>0.05; **, p<0.01.