Table 8.
Top genes in Freeman Sheldon syndrome exomes after comparison to Miller syndrome Exomes.
| Rank | GeneSymbol | Residuals | FSS p-value | Miller p-value |
|---|---|---|---|---|
| 1 | MYH3 | -0.92 | 0.000 | 0.946 |
| 2 | MYH7B | -0.72 | 0.032 | 0.745 |
| 3 | GCN1L1 | -0.28 | 0.049 | 0.247 |
| 4 | MLL3 | -0.23 | 0.032 | 0.164 |
| 5 | POTED | -0.22 | 0.031 | 0.159 |
| 6 | FRG2C | -0.20 | 0.013 | 0.108 |
| 7 | KCNJ18 | -0.17 | 0.001 | 0.058 |
| 8 | SLC12A3 | -0.13 | 0.044 | 0.061 |
| 9 | BCLAF1 | -0.12 | 0.005 | 0.008 |
| 10 | OR4C3 | -0.12 | 0.002 | 0.004 |
After comparing gene scores in Freeman Sheldon syndrome (FSS) exomes to Miller syndrome exomes using a linear model, genes are re-sorted on residuals. Here, small negative residuals indicate genes that were more significant in Freeman Sheldon syndrome exomes relative to Miller syndrome exomes.