Figure 3. HydH5SH3b and HydH5Lyso cleavage sites on the peptidoglycan structure of S. aureus.
The glycan chain consists of β- 1,4- linked monomers of N-acetyl glucosamine (GlcNAc) and N-acetyl muramic acid (MurNAc). The stem peptide contains amino acids L-Ala, D-iGln, L-Lys and D-Ala. This peptide is cross-linked to an opposite stem peptide on a separate glycan polymer through a pentaglycine (Gly5) interpeptide bridge. Arrows indicate the bonds targeted by the lytic proteins.