Table 2. Correlation of metabolic traits with expression of phospholipid biosynthesis genes in different tissues of non-diabetic subjects.
Tissue | Gene | BMI | WHR | PFAT | SI | SI* | |
Adipose | N | 142 | 138 | 142 | 131 | 131 | |
PCYT2 | r | −0.34 | −0.18 | −0.30 | 0.34 | 0.25 | |
p | 3.60E-05 | 0.039 | 4.15E-04 | 7.15E-05 | 0.005 | ||
PCYT1A | r | 0.26 | 0.24 | 0.36 | −0.05 | 0.08 | |
p | 0.002 | 0.004 | 1.09E-05 | 0.571 | 0.383 | ||
PEMT | r | 0.43 | 0.37 | 0.46 | −0.33 | −0.19 | |
p | 1.12E-07 | 8.83E-06 | 9.57E-09 | 1.37E-04 | 0.029 | ||
PTDSS2 | r | 0.21 | 0.24 | 0.29 | 0.04 | 0.15 | |
p | 0.014 | 0.006 | 4.72E-04 | 0.675 | 0.094 | ||
Muscle | N | 147 | 143 | 147 | 127 | 127 | |
PCYT2 | r | −0.12 | −0.11 | −0.12 | 0.28 | 0.26 | |
p | 0.16 | 0.18 | 0.15 | 0.002 | 0.005 | ||
PCYT1A | r | −0.03 | 0.04 | 0.04 | 0.15 | 0.14 | |
p | 0.75 | 0.63 | 0.67 | 0.10 | 0.12 | ||
PEMT | r | −0.01 | −0.04 | −0.02 | 0.16 | 0.17 | |
p | 0.92 | 0.67 | 0.80 | 0.07 | 0.06 | ||
PTDSS2 | r | 0.01 | 0.00 | 0.01 | 0.12 | 0.13 | |
p | 0.93 | 0.997 | 0.88 | 0.18 | 0.14 | ||
SVF | N | 40 | 39 | 40 | 37 | 37 | |
PEMT | r | −0.13 | 0.26 | 0.05 | −0.03 | −0.11 | |
p | 0.44 | 0.13 | 0.76 | 0.88 | 0.54 | ||
Adipocyte | N | 39 | 38 | 39 | 36 | 36 | |
PEMT | r | 0.37 | 0.57 | 0.38 | −0.34 | −0.19 | |
p | 0.024 | 3.68E-04 | 0.022 | 0.051 | 0.30 |
r, partial correlation after controlling for age, gender, ethnicity; *, partial correlation after controlling for age, gender, ethnicity, and ln(BMI); BMI, body mass index; WHR, waist-to-hip ratio; PFAT, percent of fat mass (measured by DXA). N = sample number, p = p-value; SVF, stromal vascular fraction.