Table 3. WHR-associated SNPs in PEMT modulate its transcript level expression in subcutaneous adipose tissue.

					All (N = 154)				Caucasian non diabetics (N = 101)
SNP	Location (hg19)	Annotation	Allele1*	WHR* P-value	Genotype count	Allele1*	P	Padj	Genotype count	P	Padj
s7946	7409560	missense	G	0.016	AA/AG/GG	G	0.151	0.16	AA/AG/GG	0.023	0.080
		V 175 M			64/74/16				53/45/3
s4646404	17420199	intron	G	3.07E-06	GG/AG/AA	G	0.053	0.09	GG/AG/AA	0.024	0.068
					97/44/12				54/35/11
s897453	17425631	missense	C	6.00E-05	CC/TC/TT	C	0.016	0.008	CC/TC/TT	0.010	0.009
		V 58 I			77/55/21				39/42/20
s4646343	17492077	intron	C	2.47E-05	CC/AC/AA	C	0.004	9.16E-04	CC/AC/AA	6.21E-04	4.10E-04
					69/59/26				37/42/22

^*, Allele 1, Trait increasing allele; P, ANOVA P-value for transcript expression level; P adj, statistical significance of genotypic association from univariate analysis of variance using a general linear model (GLM) procedure that included age as covariates and genotype, gender, ethnicity as fixed factors; WHR P-value, P-value for WHR adjusted for BMI as in GIANT data.