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The dual functionality of DAP-F(p)-NOH or DAP-CF3(p)-NOH compounds. The reductive environment of the cancer cells shifts the equilibrium balance, such that less antioxidant cytoprotection is afforded to cancer cells versus normal cells. The –NOH (N-hydroxy-pyrroline) moiety undergoes conversion to and exists in equilibrium with the nitroxide (>NO) form (shown in the circle).
