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Sequence signatures among class V POU family proteins. Within the N-terminal domain, the only motif present in all family members is boxed (A). Within the POU domain, position (B) is a glutamic acid residue in all POU2 orthologs and an aspartic acid residue in all POU5F1 orthologs. Single-residue deletions at (C) and (D) are specific to boroeutherian POU5F1 and all POU5F1 orthologs, respectively.
