Table 2.

Diagnostic accuracy of very low cerebral blood volume (VLCBV) for parenchymal hematoma (PH) and symptomatic intracerebral hemorrhage (sICH).

PH	Sens	Spec	PPV	NPV	LR	AUC*
DEFUSE (n=69)	100% (66–100%)	72% (59–83%)	35% (17–56%)	100% (92–100%)	3.5 (2.4–5.3)	0.89 (0.80–0.97)
EPITHET-DEFUSE (all, n=163)	96% (78–100%)	61% (53–70%)	29% (19–40%)	99% (94–100%)	2.5 (2.0–3.1)	0.81 (0.74–0.88)
EPITHET-DEFUSE (excluding VLCBV regions that did not reperfuse n=144)	100% (79–100%)	78% (70–85%)	36% (22–52%)	100% (96–100%)	4.6 (3.3–6.3)	0.86 (0.80–0.93)
EPITHET-DEFUSE (excluding VLCBV regions that did not reperfuse in tPA group only n=101)	100% (74–100%)	83% (74–90%	44% (25–65%)	100% (95–100%)	5.9 (3.7–9.4)	0.90 (0.83–0.96)
sICH (SITS)	Sens	Spec	PPV	NPV	LR	AUC*
DEFUSE (n=69)	100% (40–100%)	66% (53–77%)	15 (4.4–35%)	100% (92–100%)	3.0 (2.1–4.2)	0.89 (0.77–1.0)
EPITHET-DEFUSE (all, n=163)	88% (47–100%	55% (47–63%)	9.2% (3.8–18.1%)	99% (94–100%)	2.0 (1.4–2.7)	0.75 (0.63–0.88)
EPITHET-DEFUSE (excluding VLCBV regions that did not reperfuse n=144)	100% (29–100%	71% (63–78%)	6.8% (1.4–19%)	100% (96–100%)	3.4 (2.7–4.5)	0.91 (0.83–0.99)
EPITHET-DEFUSE (excluding VLCBV regions that did not reperfuse in tPA group only n=101)	100% (29–100%)	76% (66–84%)	11% (2.4–29%)	100% (95–100%)	4.1 (2.9–5.8)	0.94 (0.88–1.0)

Sens: Sensitivity, Spec: Specificity, PPV: Positive Predictive Value, NPV: Negative Predictive Value, LR: Likelihood ratio with 95% confidence intervals, using VLCBV>2mL dichotomy reported with 95% confidence interval, AUC: area under curve *using VLCBV as a continuous variable. sICH SITS definition (PH2 + ≥4 point NIHSS deterioration)