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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: Prog Lipid Res. 2013 Mar 14;52(3):249–276. doi: 10.1016/j.plipres.2013.02.002

Figure 1. The initiation module of type II fatty acid synthesis.

Figure 1

The priming reaction for the elongation cycle is performed by the by the initiating condensing enzyme, FabH, which condenses an acyl-CoA with malonyl-ACP. In bacteria that produce straight chain fatty acids (SCFA), acetyl-CoA is employed. Bacteria producing branched-chain fatty acids (BCFA) utilize an amino acid derived branched chain acyl-CoA precursor. Malonyl-CoA is formed by acetyl-CoA carboxylase, which is composed of four different protein subunits encoded by separate genes (AccABCD). Malonyl-ACP is formed by the transacylase, FadD.