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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: Int J Radiat Oncol Biol Phys. 2013 Mar 21;86(3):414–419. doi: 10.1016/j.ijrobp.2012.12.027

Table 5.

Mean EQD210 for D95% of CTV and ITV for A lung isotoxic and B to normal tissue tolerance plans.

Plans CTV PT
(SD)		 ITV PT
(SD)		 CTV LN
(SD)		 ITV LN
(SD)
Plan A
1. EQD210 at max dose step without increasing mean lung dose 64.4 (6.3) 72.0 (8.3) 52.7 (2.8) 54.9 (3.6)
2. 1. and not exceeding any normal tissue tolerance 61.6 (7.1) 67.7 (11.6) 52.9 (2.7) 54.4 (3.4)
p-values 2. versus 66 Gy <0.01 <0.01 >0.05 >0.05
Plan B
3. EQD210 at max dose step without exceeding lung tolerance 66.1 (7.5) 72.2 (10.1) 54.1 (2.5) 55.7 (3.1)
4. 3. and not exceeding any normal tissue tolerance 63.4 (7.7) 68.2 (11.1) 54.1 (2.5) 55.6 (3.0)
p-values 4. versus 66 Gy <0.01 <0.01 <0.025 <0.025

CTV: clinical target volume; D95% dose in 95% of the volume; ITV: internal target volume; LN: lymph nodes; EQD210 dose equivalent to 2 Gy dose for α/β=10 Gy; PT: primary tumor; SD: standard deviation.