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. 2013 May 24;11:131. doi: 10.1186/1479-5876-11-131

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Copyright © 2013 Tront et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Gadd45A expression levels in human breast cancer samples are dependent on the hormone receptor subtype. (A) Box and Whisker Plots graphically depict the expression pattern of Gadd45a in the subtypes of human breast cancer. There was a highly significant difference in percent Gadd45a staining between groups: Normal 16.3%; Luminal A 65.3%; Luminal B 85.7%; HER2+ 40.5%; TN 31.2%, P < 0.001, ANOVA. (B) Representative images from immunohistochemical analysis of Gadd45a of Normal (a), Luminal A (b), Luminal B (c), Her2+ (d) and Triple Negative (e) breast tissue. Immunostaining was reviewed and scored by three independent observes. Percent positive stainings for each specimen were averaged and categorized as: Negative (0- < 10%, Neg), Low (10–<40%), Medium (40–<70%, Med), or High (≥70%).